ProcessDB Wiki  Computational Cell Biology Textbook

IBI's product offering, ProcessDB, helps molecular cell biologists manage and test their increasingly complex mechanistic hypotheses. ProcessDB does this with a bio-savvy graphical user interface that helps users formulate, visualize, compare, modify, manage and test their own mechanistic theories of cellular function. All models in ProcessDB can be automatically combined with user-specified experimental protocols. The models can be exported to the Berkeley Madonna solver for testing against experimental data or they can be solved using our new integrated solver.

ProcessDB version 5.0, released in 2014, is a major upgrade from version 4. The most significant change is the increased speed of the data transfer between the application on your desktop and our central database server. This is particularly noticible to our clients in countries outside of the US. We have also made improvements to our solver interface.

It is possible to solve models without leaving the ProcessDB environment. We have implemented an extremely fast version of the famous CVODE ordinary differential equation solver, which benchmarks have shown averages sixteen times faster than the same problem solved in the Berkeley Madonna environment. Solver output is displayed in a flexible graphing interface that allows any model variable to be plotted and compared to experimental data. Modelers will be happy to learn that we have also implemented the new and already popular "particle swarm" algorithm for searching parameter space during least squares parameter optimization. Particle swarm searching was designed to find global minima in least squares space. It is resistant to being trapped in a local minimum and thus finds better solutions to complex multiparameter optimization problems. We will continue to support the Berkeley Madonna software, but we think you will find that an integrated solver and optimizer greatly speeds your work.

ProcessDB allows investigators to know with precision what their theories predict, and speeds discovery of mechanisms that account for all of the available data. ProcessDB, which is accessable from any Internet-connected computer, offers a highly secure and professionally-maintained tool that supports mechanistic knowledge management for research laboratories working on complex biological or biomedical problems.

To find out more about ProcessDB and the modeling of biological systems, the following information is available:

ProcessDB Wiki: this is the most current version of the ProcessDB user guide as it is continually updated as we add new features to the software.

Computational Cell Biology Textbook: This online textbook can be used by advanced undergraduate and graduate students and professionals in the biomedical sciences or in biomedical engineering who want or need to use modern computer modeling approaches to test theories against experimental data. The textbook is focused on practical application; it is a handbook, a guidebook, and a map for the process of formulating and testing biological models. The reader will learn a step-by-step method, applicable to a wide range of biological problems.