NEWS & EVENTS
September 2007
Integrative BioInformatics part of a team receiving an NIH Roadmap Grant

Integrative BioInformatics announces its collaboration with a team based at the University of Texas Southwestern (UTSW) Medical Center, which has just received a $22 million grant from the National Institutes of Health. The award, formally announced on September 6, 2007, will fund UTSW Medical Center’s obesity research team in its groundbreaking multi-prong attack on obesity, from studying individual fat cells to developing medicines. Integrative BioInformatics will provide software and expert consulting services to the project team.
UT Southwestern's obesity research receives $22 million NIH Roadmap grant

July 2007
Integrative BioInformatics Awarded NIH Grant to Create an Integrated Model of Protein and Membrane Traffic in the Secretory Pathway

The major goals of this two-year grant are to formulate and test a mechanistic kinetic model of the secretory pathway that integrates five key subsystems or modules: cargo protein, glycerophospholipieds, sphingolipids, cholesterol, and resident Golgi protein. The work will be done in collaboration with Dr. Jennifer Lippincott-Schwartz and her lab in the Cell Biology and Metabolism Branch of the NICHD.

June 2007
Scientists Discover Role of Enzyme in DNA Repair

Scientists at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have made what may be a crucial discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body's ability to repair damaged DNA.

When DNA within a cell is damaged, the cell's protective mechanism must do one of two things: repair the defect or "commit suicide," says Rafael Casellas, Ph.D., an investigator in NIAMS' Molecular Immunology and Inflammation Branch and leading author of a new paper describing the discovery. But the way in which the cell performs these protective functions has been largely a mystery, says Casellas, whose research is beginning to unravel this mystery.

Integrative BioInformatics, Inc. has been collaborating with Dr. Casellas on this ground-breaking work.

December 2006
Integrative BioInformatics, Inc. will be represented at the 46th annual meeting of The American Society for Cell Biology in San Diego. To speak with one of our representatives, click on the Contact Us link above and indicate your area of interest.

July 2006
IBI participated in the Woods Hole Marine Biological Laboratory's annual Summer Course in Physiology. The Marine Biological Laboratory offers advanced graduate-level courses for six to nine weeks each summer. Our software, ProcessDB, was used in an intensive laboratory course that provided a unique interdisciplinary training environment at the interface between cellular and computational biology. Students with backgrounds in both the biological and physical / computational sciences participated in the course.

June 2006
Dr. Madi Lapidot, an IBI consulting scientist, gave presentations about ProcessDB at several sites in Israel. Dr. Lapidot visited the Shav-Tal Lab at Bar-Ilan University, one of IBI’s clients. In addition, a presentation was given at Compugen, a Biotech firm, in Tel-Aviv, and at Joseph Kost’s lab in Chemical Engineering at Ben-Gurion University of the Negev. Audiences in Israel were enthusiastic to hear about ProcessDB and the possibilities of modeling with this new software.

December 2005
IBI introduced the latest version of its flagship software product, ProcessDB, on the exhibit floor at the 45th annual meeting of The American Society for Cell Biology in San Francisco.

September 2005
Dr. Phair, IBI's chief science officer, was invited to present a talk on applications of ProcessDB at the Chemical Industry Institute of Toxicology (CIIT) in Research Triangle Park, North Carolina. Discussions with CIIT investigators raised the possibility of new ProcessDB applications in physiologically based pharmacokinetic modeling (PBPK).

July 2005
IBI competed for and won a spot in the NIH Commercialization Assistance Program (CAP). The NIH CAP is a highly selective program designed to assist SBIR Phase II supported technologists with the business and marketing challenges that we face in progressing from development to commercial product.

May 2005
IBI's principals were selected to participate in the 2005 SBML Hackathon in Tokyo, Japan. During this annual programming event, our team was able, for the first time, to export models stored in ProcessDB using the widely adopted XML format for model interchange. ProcessDB models can now be imported by over 90 software applications that support this emerging standard.

March 2005
IBI's principals organized and participated in the Software Workshops at the 3rd Computational Cell Biology Symposium in Lenox, Massachusetts organized by the National Resource for Cell Analysis and Modeling. This meeting has become so successful that it has now been adopted by the Cold Spring Harbor Laboratory.

December 2004
Dr. Phair, with one of IBI's principal experimental collaborators, Dr. Jennifer Lippincott-Schwartz, was invited to present a "tag-team" talk at the annual meeting of the American Society for Cell Biology on the contributions of ProcessDB and kinetic modeling to a new paradigm-shifting theory of Golgi function.

October 2004
IBI was selected to present a full-day workshop on analysis of photobleaching and photoactivation experiments at the 2004 International Congress on Systems Biology in Heidelberg, Germany. The workshop using an early version of ProcessDB was oversubscribed, but fortunately we found enough computers so that everyone could be accommodated. This event provided us with valuable feedback, especially from the two teaching assistants we recruited from Jan Ellenberg's lab at EMBL.

February 2004
IBI's Phase II Small Business Innovative Research grant application was approved and subsequently funded funded by the NIGMS. This grant supports continued development of our ProcessDB software.